Grapefruit Warning: Medicine Interaction List Expanded; Are You At Risk?

By IScience Times Staff Reporter on November 27, 2012 10:54 PM EST

A new report states that 43 medications can cause serious side effects when taken within 24 hours of grapefruit consumption.
A new report states that 43 medications can cause serious side effects when taken within 24 hours of grapefruit consumption. (Photo: Reuters)

Grapefruit interaction warnings are nothing new. But now doctors are expanding the list of medicines that can't be taken with the fruit, based on a new report released by the Canadian Medical Association Journal.

According to researchers at the University of Western Ontario the 17 drugs that were identified in 2008 as potential problems only represented a small fraction of prescriptions that could be dangerous when taken with grapefruit or grapefruit juice. The revised list has grown to an alarming 43 medications. Scroll down for the full list below.

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"The frequency of these reactions may be small, but the risks are not worth it, especially for drugs which could cause sudden death," said lead study author David Bailey, a professor of pharmacology and one of the first to notice problems with grapefruit juice and medication interaction. "Physicians need to know that this affects a number of new drugs and apply this information to their practice and patients."

It's hard to believe that a piece of fruit could cause such grave problems. But a chemical contained in grapefruits, furanocoumarins, has been proven to interrupt the breakdown of certain drugs in the body. When the medications can't break down properly, the drug causes the equivalent of an over-dose effect that, in some cases, can be toxic.

Even without fatal side effects, a grapefruit interaction can provoke severe symptoms like heart rhythm problems, kidney failure, muscle breakdown, difficulty with breathing and blood clots. Atorvastatin, often known by the brand name Lipitor, and heart medications like Verapamil and Amiodarone are three of the medications that can cause the biggest issues.

Bailey emphasizes that even consumption of one grapefruit or an 8-ounce glass of grapefruit juice can prompt severe side effects when a medication is taken within 24 hours. Seville oranges, limes, and pomelos can spur the same problem.

If you're concerned, contact a physician or pharmacist. To get started, we've included the expanded grapefruit warning list below:

A-C

Alfentanil (oral)
Amiodarone
Apixaban
Atorvastatin
Buspirone
Clopidogrel
Crizotinib
Cyclosporine

D-F
Darifenacin
Dasatinib
Dextromethorphan
Domperidone
Dronedarone
Eplerenone
Erlotinib
Erythromycin
Everolimus
Felodipine
Fentanyl (oral)
Fesoterodine

H-P
Halofantrine
Ketamine (oral)
Latatinib
Lovastatin
Lurasidone
Maraviroc
Nifedipine
Nilotinib
Oxycodone

P-Z
Pazopanib
Pimozide
Primaquine
Quinine
Quetiapine
Quinidine
Rilpivirine
Rivaroxaban
Silodosin
Simvastatin
Sirolimus
Solifenacin
Sunitinib
Tacrolimus
Tamsulosin
Ticagrelor
Triazolam
Vandetanib
Venurafenib

Verapamil
Ziprasidone

© 2012 iScience Times All rights reserved. Do not reproduce without permission.

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